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KMID : 0861020120270020069
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Korea Journal of Herbology
2012 Volume.27 No. 2 p.69 ~ p.75
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Mountain cultivated ginseng water boiled extract decreases blood glucose level and improves lipid metabolism in male db/db mice
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Kim Eung-Lae
Kim Chang-Sik
Lee Hee-Young
Lee Hye-Rim
Kim Eung-Yeol
Yoon Mi-Jung
Shin Soon-Shik
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Abstract
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Objectives: We investigated the effects of mountain cultivated ginseng water boiled extract(MCG) on blood
glucose and insulin levels, and examined whether lipid metabolism are improved by it in male db/db mice(a
murine model of type 2 diabetes mellitus).
Methods: 9 weeks old, male db/db mice were divided into 5 groups： C57BL/6J normal, control, MCG-250㎎/㎏
(MCG-1), MCG-500㎎/㎏(MCG-2) and MCG-1000㎎/㎏(MCG-3). After mice were treated with MCG for 8 weeks,
we measured body weight, food intake, fat weight, visceral organ weight and blood glucose, insulin and lipid
levels.
Results: 1. We found no difference in body weight, food intake, fat weight and visceral organ weight among
the animal groups.
2. Compared with controls, MCG-treated mice had lower blood glucose level and higher blood insulin levels, the
magnitude of which was prominent in MCG-2.
3. Compared with controls, MCG-treated mice had lower LDL-cholesterol and higher HDL-cholesterol levels.
4. Compared with controls, MCG-treated mice had blood triglyceride and free fatty acid levels, the magnitude
of which was prominent in MCG-2.
5. Blood AST and ALT concentrations were not changed by MCG, indicating MCG do not show any toxic
effects.
Conclusions: These results demonstrate that MCG effectively increases blood insulin level and decreases blood
glucose level, blood lipid levels, and prevents and improves diabetic dyslipidemia and cardiovascular disease.
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KEYWORD
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mountain cultivated ginseng(MCG), diabetes, glucose, triglyceride, insulin, dyslipidemia
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